Antibodies to Beta 2-Glycoprotein-I, Apolipoprotein-H, APO-H

Beta 2-Glycoprotein-I (Apolipoprotein-H, APO-H), human

Antibody Host Catalogue No. Size Product Insert
purified IgG Goat GAB2G-IG 5 mg
affinity purified IgG Goat GAB2G-AP 0.5 mg
peroxidase conjugated IgG Goat GAB2G-HRP 0.2 mg
Matched Pair Antibodies
– Matched Pair Antibodies for EIA   APOH-EIA 5 plates

Description of Beta2 Glycoprotein-I (Apolipoprotein-H, APO-H)

Apolipoprotein-H, also known as β2-Glycoprotein I (β2GPI), is a plasma glycoprotein that circulates at a concentration of 200 ug/ml (4 μM). Synthesized in the liver, β2GPI is a single chain molecule of 48 kDa, consisting of five repeating internally disulphide-bonded structures referred to as sushi domains. Relative to other glycoproteins, β2GPI has an unusually high content of cysteine (6.2%), proline (8.3%) and carbohydrate (19%). Almost half the circulating β2GPI in plasma is associated with lipoproteins of all major fractions. β2GPI has been demonstrated to bind negatively charged phospholipids, heparin and platelets. Although the precise function(s) are as yet unknown, β2GPI has been demonstrated to interfere with blood coagulation by competitively binding to negatively charged phospholipid surfaces exposed during cell activation or damage. Recent evidence also implicates β2GPI as a cofactor recognized by anti-phospholipid antibodies present in some autoimmune disorders such as systemic lupus erythematosus (SLE)1-3.

References:

1. Lee, NS, Brewer HB Jr., Osborne JC Jr.; β2Glycoprotein I: Molecular Properties of an Unusual Apolipoprotein, Apolipoprotein H;

JBC 258, pp 4765-4770, 1983.

2. Schousboe I; β2Glycoprotein I: A Plasma Inhibitor of the Contact Activation of the Intrinsic Blood Coagulation Pathway. Blood 66, pp 1086-1091, 1985.

3. Nimpf J, Bevers EM, Bomans PHH, Till U, Wurm H, Kostner GM, Zwaal RFA; Prothrombinase activity of human platelets is inhibited by β2Glycoprotein I; Biochimica et Biophysica Acta 884, pp 142-149, 1986.

Related Products:

GAB2G-AP Goat anti-human APO-H, affinity purified IgG

GAB2G-HRP Goat anti-human APO-H, IgG-peroxidase conjugate

APOH-EIA Paired antibody set for ELISA of β2GPI, 5 x 96 wells

APOH-DP Human plasma deficient in APO-H, immune depleted, Frozen
APOH-LDP Human plasma deficient in APO-H, immune depleted, Lyophilized