Beta 2-Glycoprotein-I (Apolipoprotein-H, APO-H), human
|Antibody||Host||Catalogue No.||Size||Product Insert|
|purified IgG||Goat||GAB2G-IG||5 mg|
|affinity purified IgG||Goat||GAB2G-AP||0.5 mg|
|peroxidase conjugated IgG||Goat||GAB2G-HRP||0.2 mg|
|Matched Pair Antibodies|
|– Matched Pair Antibodies for EIA||Ã‚Â||APOH-EIA||5 plates|
Description of Beta2 Glycoprotein-I (Apolipoprotein-H, APO-H)
Apolipoprotein-H, also known as ÃŽÂ²2-Glycoprotein I (ÃŽÂ²2GPI), is a plasma glycoprotein that circulates at a concentration of 200 ug/ml (4 ÃŽÂ¼M). Synthesized in the liver, ÃŽÂ²2GPI is a single chain molecule of 48 kDa, consisting of five repeating internally disulphide-bonded structures referred to as sushi domains. Relative to other glycoproteins, ÃŽÂ²2GPI has an unusually high content of cysteine (6.2%), proline (8.3%) and carbohydrate (19%). Almost half the circulating ÃŽÂ²2GPI in plasma is associated with lipoproteins of all major fractions. ÃŽÂ²2GPI has been demonstrated to bind negatively charged phospholipids, heparin and platelets. Although the precise function(s) are as yet unknown, ÃŽÂ²2GPI has been demonstrated to interfere with blood coagulation by competitively binding to negatively charged phospholipid surfaces exposed during cell activation or damage. Recent evidence also implicates ÃŽÂ²2GPI as a cofactor recognized by anti-phospholipid antibodies present in some autoimmune disorders such as systemic lupus erythematosus (SLE)1-3.
1. Lee, NS, Brewer HB Jr., Osborne JC Jr.; ÃŽÂ²2Glycoprotein I: Molecular Properties of an Unusual Apolipoprotein, Apolipoprotein H;
JBC 258, pp 4765-4770, 1983.
2. Schousboe I; ÃŽÂ²2Glycoprotein I: A Plasma Inhibitor of the Contact Activation of the Intrinsic Blood Coagulation Pathway. Blood 66, pp 1086-1091, 1985.
3. Nimpf J, Bevers EM, Bomans PHH, Till U, Wurm H, Kostner GM, Zwaal RFA; Prothrombinase activity of human platelets is inhibited by ÃŽÂ²2Glycoprotein I; Biochimica et Biophysica Acta 884, pp 142-149, 1986.
GAB2G-AP Goat anti-human APO-H, affinity purified IgG
GAB2G-HRP Goat anti-human APO-H, IgG-peroxidase conjugate
APOH-EIA Paired antibody set for ELISA of ÃŽÂ²2GPI, 5 x 96 wells