Neutrophil Elastase – ELA-2 Antibodies

Affinity Biologicals, Inc. manufactures a broad range of Neutrophil Elastase – ELA-2 Antibodies which can be found in the listing below.   Further information about each individual Neutrophil Elastase – ELA-2 Antibody is available by following the associated links.  Our Neutrophil Elastase – ELA-2 Antibodies are excellent for use in immunoassays where high sensitivity is required and are frequently the preferred reagent for immunopreciptaion techniques and activity neutralization assays.  These antibodies have proven to be extremely useful in the preparation of immune-adsorbent resins for use in immuno-depletion of specific proteins from plasma as well as immuno-affinity purification of proteins.  Affinity’s Neutrophil Elastase – ELA-2 Antibodies are manufactured for use in research applications.

Listing of Neutrophil Elastase – ELA-2 Antibodies

Neutrophil elastase – NE

Neutrophil elastase – NE also called elastase-2 or ELA-2 is a powerful serine protease stored in the primary granule of neutrophils.1  This enzyme is synthesized primarily at the promyelocyte stage of neutrophil development in the bone marrow. The human gene for NE is located at 19 p 13.3, and mutations in NE are regarded as the primary cause of cyclic neutropenia and some, but not all, cases of severe congenital neutropenia.2-4

References and Reviews

  1. Gullberg U, Andersson E, Garwicz D, Lindmark A, Olsson I. Biosynthesis, processing and sorting of neutrophil proteins: insight into neutrophil granule development. Eur J Haematol. 1997;58: 137-153.
  2. Horwitz M, Benson KF, Person RE, Aprikyan AG, Dale DC. Mutations in ELA2, encoding neutrophil elastase, define a 21-day biological clock in cyclic hematopoiesis. Nat Genet. 1999;23: 433-436.
  3. Dale DC, Person RE, Bolyard AA, et al. Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia. Blood. 2000;96: 2317-2322.
  4. Ancliff PJ, Gale RE, Leisner R, Hann IM, Linch DC. Mutations in the ELA2 gene encoding neutrophil elastase are present in most patients with sporadic severe congenital neutropenia but only in some patients with the familiar form of the disease. Blood. 2001;98: 2645-2650.