Thrombosis Research: Commonly Used Products and Their Applications

Thrombosis and embolism are a huge health problem in the United States. According to figures provided by the CDC, up to 100,000 Americans die as a result of contracting Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE) each year. Fact of the matter is that all the deaths and suffering caused by these blood clots is entirely preventable; however the resulting mortality rate remains higher than that caused by AIDS, breast cancer and traffic accidents, combined! This is why it is becoming increasingly important to invest time, money and resources into thrombosis research and find a permanent solution to the health problem. However, research, investigations and enquiries are only as good as the accuracy of the products, mediums and machines used. Affinity Biologicals offers an exclusive line of products that have been used far and wide in the research industry. Hundreds of researchers trust and cite the results acquired from these research-ready products in the last 25 years. Some of their most important products for thrombosis research include:

Coagulation Antibodies

Thrombosis Research mandates a wide range of monoclonal and polyclonal antibodies. These are used to key coagulation related biomarkers and also for accurately diagnosing assay development. The coagulation antibodies used during research include Fibrinogen and the von Willebrand Factor (vWF), among many others offered by Affinity Biologicals. calibrator-plasmasThe vWF carries and steadies the pro-coagulant protein Factor VIII by binding to it and protecting it. The huge glycoprotein also delivers the pro-coagulant to sites of vascular injury. The insufficiency or structural defect of vWF and FVIII leads to the common hereditary blood disorders, von Willenbrand’s disease (VWD) and also hemophilia A (HA). Fibrinogen is another plasma glycoprotein that is synthesized in the liver, and holds a place of importance in the coagulation cascade.   Fibrinogen is converted to fibrin, and interacts with various proteins and cells. This is why a fibrinogen activity test is often considered the perfect indicator for a possible bleeding disorder or cardiovascular disease.

Matched-Pair Antibody Sets

Enzyme-Linked Immunosorbent Assays (ELISAs) are plate-based assays specifically created for discovering and quantifying substances such as peptides, proteins, antibodies and hormones. Affinty makes a wide range of matched antibody pairs that have been thoroughly tested in a sandwich ELISA to diagnose the recombinant protein.

Coagulation Control Plasmas

Coagulation Quality Control Plasmas are crucial components of diagnostic and research where coagulation assays are carried out. Affinity Biologicals’ coagulation controls are being extensively used all over the research industry as reference materials for coagulation tests to ensure the best quality, reliable and consistent results.

Applications of These Products in Thrombosis Research

Affinity Biologicals provides a variety of Coagulation and Thrombosis research products that are sourced internally and made in accordance with ISO standards for medical device quality assurance. These and hundreds of other products are routinely employed during clinical trials and outcome studies, pharmacokinetic and genetic testing, platelet function testing, antithrombotic drug development, research consulting and also protocol development. In addition to vascular biology and thrombosis research, these products can be of help during research for treatment of myocardial infarction, fibrinolytic therapy, antiplatelet therapy and many other catheter-based treatments of vascular disease. As pioneers and world leaders in the field of antithrombotic research products, Affinity Biologicals have had their products referenced in many research papers and other research related documents. These products include a line-up of antibodies for coagulation, hemostasis related proteins, antibody pairs for immunoassay of human and animal analytes, the VisuLizeâ„¢ line of ELISA kits, and an all inclusive line-up of human plasma products. The company also offers custom Services including protein purification, antibody production, assay development and lyophilization.