Antibodies to vWF – von Willebrand Factor

von Willebrand Factor, human

Antibody Host Catalogue No. Size Product Insert
Purified IgG Goat GAVWF-IG 2.5 mg
Affinity purified IgG Goat GAVWF-AP 0.5 mg
Peroxidase Conjugated IgG Goat GAVWF-HRP 0.15 mg
Affinity purified, FITC conjugated IgG Goat GAVWF-APFTC 0.1 mg
Affinity purified, biotinylated IgG Goat GAVWF-APBIO 0.1 mg
Matched Pair Antibodies for EIA VWF-EIA 5 plates
Analyte Specific Reagent
– Purified IgG Goat GAVWF-IG-ASR 2.5 mg
– Peroxidase conjugated IgG Goat GAVWF-HRP-ASR 0.15 mg

von Willebrand Factor, canine

Antibody Host Catalogue No. Size Product Insert
Purified IgG Sheep SACWF-IG 5 mg
Peroxidase conjugated IgG Sheep SACWF-HRP 0.2 mg

von Willebrand Factor, Rat

Antibody Host Catalogue No. Size Product Insert
Purified IgG Sheep SARTW-IG 5 mg
Peroxidase conjugated IgG Sheep SARTW-HRP 0.2 mg

Description of von Willebrand Factor -vWF

von Willebrand Factor (vWF, also previously referred to as Factor VIII related antigen) is a large adhesive protein produced in endothelial cells and megakaryocytes. There are two critical functions of vWF, the first being its involvement in the process of platelet adhesion and aggregation through interaction with platelet receptor glycoprotein Ib, the second being the binding and stabilization of Factor VIII (antihemophilic factor) for secretion and transport in plasma. The vWF precursor protein is synthesized with a 95,000 dalton propeptide (also known as vWF antigen-II), believed to be involved in the intracellular multimerization of the vWF subunits. The mature vWF multimers are then packed into storage organelles within the cell (Weibel-Palade bodies) after which the propeptide is cleaved and released. vWF circulates as multimers of disulphide linked 220,000 dalton subunits and the molecular weight of these multimers ranges from 0.5-20 million daltons.

The plasma concentration of vWF is typically 10 μg/ml, but increased levels are often observed in pregnancy and other conditions of physiological stress. von Willebrand’s disease (vWD) is perhaps the most common inherited bleeding disorder in humans and is the result of either quantitative deficiencies of vWF (vWD Types I & III), or one of a number of qualitative disorders of vWF structure and function (vWD Type II).

References and Reviews
  1. Montgomery RR, Coller BS, in Hemostasis and Thrombosis, 3rd Edition, eds. RW Colman, J Hirsh, VJ Marder and EW Salzman, pp. 134-168, J.B. Lippincott Co., Philadelphia PA,.USA, 1994.
  2. Sadler JE; von Willebrand Factor (Minireview); JBC 266:34, pp 22777-22780, 1991.