Antibodies to Factor V

Factor V, human

Antibody Host Catalogue No. Size Product Insert
Purified IgG Sheep SAFV-IG 10 mg Factor V Polyclonal Antibody - whole IgG Factor V (FV, F5) polyclonal antibody - purified IgG - sheep - Affinity Biologicals
Affinity purified IgG Sheep SAFV-AP 0.5 mg F5 antibody - polyclonal coagulation factor v - affinity purified Factor V (FV, F5) polyclonal antibody - affinity purified IgG - sheep - Affinity Biologicals
Peroxidase conjugated IgG Sheep SAFV-HRP 0.2 mg Anti-human factor v antibody Factor V (FV, F5) polyclonal antibody - peroxidase conjugate IgG - sheep - Affinity Biologicals
Affinity purified, FITC conjugated IgG Sheep SAFV-APFTC 0.1 mg Antibodies to Factor V Factor V (FV, F5) - polyclonal antibody - sheep - affinity purified FITC conjugated IgG
Affinity purified, biotinylated IgG Sheep SAFV-APBIO 0.1 mg Factor V (FV, F5) - polyclonal antibody - sheep - affinity purified biotinylated conjugated IgG
Matched Pair Antibodies for EIA FV-EIA 5 plates Factor V (FV, F5) - matched pair antibodies for ELISA - Affinity Biologicals
 

Description of Factor V – F5

Factor V – F5 (formerly referred to as accelerator globulin and labile factor) is a large glycoprotein (320 kDa) that is produced in the liver.  The gene that encodes factor V (FV) is located on chromosome 1.  A congenital deficiency of FV is a hemorrhagic disorder inherited as an autosomal recessive disease.

The concentration of FV in plasma is typically 10 μg/mL.  FV is a pro-cofactor that is activated through limited proteolysis by thrombin, or by activated factor X in the presence of phospholipid surface.  Other physiologic activators of FV include plasmin, neutrophil elastase and platelet calpain.  The activated cofactor (FVa) is an essential component of the prothrombin activator complex, which consists of FVa, activated factor X, calcium and anionic phospholipid surface.  The intact prothrombinase complex activates prothrombin to thrombin at a rate 300,000-fold greater than activated factor X alone.  In a positive feedback loop, the thrombin generated accelerates its own generation by activating more FV to FVa.  Thrombin also acts to down-regulate FVa indirectly by activating Protein C, which inactivates FVa cofactor activity1-3.

References and Reviews
  1. Kane WH, Davie EW; Blood Coagulation Factors V and VIII: Structural and functional similarities and their relationship to hemorrhagic and thrombotic disorders.  Blood 71:539, 1988.
  2. Hoyer, LW, Wyshock EG, Colman RW, in Hemostasis and Thrombosis, 3rd Edition, eds. RW Colman, J Hirsh, VJ Marder and EW Salzman, pp. 109-133, J.B. Lippincott Co., Philadelphia, 1994.
  3. Nesheim ME, Katzmann JA, Tracy PB, Mann KG; in Methods in Enzymology 80:249, 1980.