C1 Inhibitor Polyclonal Antibody – Affinity Purified
Affinity’s C1 Inhibitor Polyclonal Antibody – Affinity Purified is the highest level of our C1 Inhibitor antibody family. During the Antigen Affinity Purification process the IgG has had any non-specific immunoglobulin fraction eliminated which enriches the specificity of the remaining immunoglobulin towards the target antigen. The result is a very high-purity product with a substantially higher titre than whole or purified IgG. Our C1 Inhibitor Polyclonal Antibody – Affinity Purified is provided in a solution of HEPES buffered saline containing 50% glycerol (v/v) and is intended for applications such as immunoblotting, immunostaining of cells and several types of immunoassays where the higher signal-to-noise ratio achieved with this enriched product is required.
Product Code: GACINH-AP
Retail Product Size: 0.5mg vial
Host Animal: Goat Anti-Human C1 Inhibitor Polyclonal Antibody – Affinity Purified
Species Cross Reactivity: View Chart
C1 Inhibitor Description
C1 Inhibitor (C1-INH), also known as C1 Esterase Inhibitor, is a part of the serpin family of proteases – alpha-1-antitrypsin (A1AT) and antithrombin (ATIII). These proteins together inactivate target proteases and produce complexes with the protein that is to be inhibited. Cl Inhibitor is the major plasma inhibitor of activated Hageman factor (Factor XII) and kallikrein¹. C1-INH also blocks activation of C1 and the classic complement pathway, without C1-INH the activation of C1, C2, and C4 occur before other inhibitors like C4b-binding protein (C4BP) and Complement Factor I or C3b/C4b inactivator can halt the cascade.
References and Reviews
- Kaplan AP, Ghebrehiwet B, Silverberg M, Sealey JE; The intrinsic coagulation-kinin pathway, complement cascades, plasma renin-angiotensin system, and their interrelationships; Crit Rev Immunol 1981 Sep;3(1):75-93.