C1 Inhibitor Polyclonal Antibody – HRP Conjugated
Affinity’s C1 Inhibitor Polyclonal Antibody – HRP Conjugated is the base level of our horseradish peroxidase conjugated C1 Inhibitor antibodies. The purity of IgG is typically 90% and is provided in a solution of HEPES buffered saline containing 50% glycerol (v/v). The titre is essentially the same as the starting antiserum and each vial typically contains the amount of IgG recovered from one milliliter of antiserum however this IgG has been conjugated with Horseradish Peroxidase as an enzyme reporter. This C1 Inhibitor Polyclonal Antibody – HRP Conjugated is generally intended for use as labeled primary antibodies in applications such as immunoassay and immunoblotting.
Product Code: GACINH-HRP
Retail Product Size: 0.2mg vial
Host Animal: Goat Anti-Human C1 Inhibitor Polyclonal Antibody – HRP Conjugated
Species Cross Reactivity: View Chart
C1 Inhibitor Description
C1 Inhibitor (C1-INH), also known as C1 Esterase Inhibitor, is a part of the serpin family of proteases – alpha-1-antitrypsin (A1AT) and antithrombin (ATIII). These proteins together inactivate target proteases and produce complexes with the protein that is to be inhibited. Cl Inhibitor is the major plasma inhibitor of activated Hageman factor (Factor XII) and kallikrein¹. C1-INH also blocks activation of C1 and the classic complement pathway, without C1-INH the activation of C1, C2, and C4 occur before other inhibitors like C4b-binding protein (C4BP) and Complement Factor I or C3b/C4b inactivator can halt the cascade.
References and Reviews
- Kaplan AP, Ghebrehiwet B, Silverberg M, Sealey JE; The intrinsic coagulation-kinin pathway, complement cascades, plasma renin-angiotensin system, and their interrelationships; Crit Rev Immunol 1981 Sep;3(1):75-93.