C1 Inhibitor Polyclonal Antibody
Affinity’s C1 Inhibitor Polyclonal Antibody is the base level of our C1 Inhibitor antibody family. The purity of IgG is typically 90% and is provided in a solution of HEPES buffered saline containing 50% glycerol (v/v). The titre is essentially the same as the starting antiserum and each vial typically contains the amount of IgG recovered from one milliliter of antiserum. This C1 Inhibitor Polyclonal Antibody is generally intended for use in applications such as immuno-precipitation, immuno-electrophoresis, immuno-depletion and activity neutralization assays.
Product Code: GACINH-IG
Retail Product Size: 5mg vial
Host Animal: Goat Anti-Human C1 Inhibitor Polyclonal Antibody
Species Cross Reactivity: View Chart
Product Datasheet: C1-Esterase Inhibitor Polyclonal Antibody, purified anti-human Goat IgG
C1 Inhibitor Description
C1 Inhibitor (C1-INH), also known as C1 Esterase Inhibitor, is a part of the serpin family of proteases – alpha-1-antitrypsin (A1AT) and antithrombin (ATIII). These proteins together inactivate target proteases and produce complexes with the protein that is to be inhibited. Cl Inhibitor is the major plasma inhibitor of activated Hageman factor (Factor XII) and kallikrein¹. C1-INH also blocks activation of C1 and the classic complement pathway, without C1-INH the activation of C1, C2, and C4 occur before other inhibitors like C4b-binding protein (C4BP) and Complement Factor I or C3b/C4b inactivator can halt the cascade.
References and Reviews
- Kaplan AP, Ghebrehiwet B, Silverberg M, Sealey JE; The intrinsic coagulation-kinin pathway, complement cascades, plasma renin-angiotensin system, and their interrelationships; Crit Rev Immunol 1981 Sep;3(1):75-93.