tPA and PAI-1 Deficient Plasma is manufactured from normal citrated human plasma that has been depleted of both tPA (Tissue Plasminogen Activator) and PAI-1 (Plasminogen Activator Inhibitor – type 1) by selective affinity immuno-adsorption using antibodies directed towards tPA and PAI-1.

Only the highest quality citrated plasma is used as starting material and in many cases the parent plasma is available as control material. Plasma products are typically buffered with the addition of HEPES to 20 mM final concentration and are available in 1.0 mL vials to litre quantities. Our tPA/PAI Deficient Plasma can be used for further manufacturing or research use only applications. It has not been validated for use in Thrombin Generation Assays.

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